Biggest Stock Movers: Avidity’s $12B Novartis Deal, Qualcomm’s Bold AI Push and Organon’s Shock Plunge

Biggest stock movers were in sharp focus Monday as U.S. stock futures edged higher on optimism around a potential US‑China trade deal and a widely expected Federal Reserve rate cut. Sentiment was also buoyed by a pivotal stretch of Big Tech earnings that could steer markets through the week. Against that backdrop, deal news, product roadmaps and sector headlines drove outsized premarket swings across health care, semiconductors, crypto infrastructure and miners.

Market snapshot: Why biggest stock movers are surging premarket

• Futures climbed as investors weighed signs of progress on trade alongside expectations for easier policy.
• A jam‑packed earnings calendar from mega‑cap tech may amplify intraday volatility.
• M&A, capital raises and executive changes set the tone for today’s biggest stock movers across sectors.

Below are the biggest stock movers to watch, with the latest catalysts and context.

Biggest stock movers: Top gainers leading the tape

Avidity Biosciences (NASDAQ: RNA) +42% — $12B Novartis buyout supercharges rare‑disease focus

• Novartis agreed to acquire Avidity Biosciences in an all‑cash deal valuing shares at $72, a 46% premium to Friday’s close.
• Strategic fit: The acquisition expands Novartis’s footprint in genetic and rare disease therapies, anchored by Avidity’s mid‑stage candidate targeting a subtype of Duchenne muscular dystrophy.
• Spinout: Avidity’s early‑stage precision cardiology assets will be spun into a new publicly traded “Spinco,” enabling focused capital allocation.
• Why it matters: For M&A‑sensitive biotech, premium takeouts can reset sentiment and often become the biggest stock movers on deal day.

Qualcomm (NASDAQ: QCOM) +17% — Bold AI accelerator roadmap takes aim at Nvidia and AMD

• New lineup: Qualcomm unveiled A1200 and AI250 accelerator cards and racks powered by its NPU technology.
  • A1200 (2026): Supports up to 768 GB of LPDDR per card for high‑capacity, lower‑cost memory.
  • AI250 (2027): Near‑memory architecture targeting 10x higher effective bandwidth with lower power consumption.
• Cadence: The company committed to an annual accelerator release cycle, mirroring the pace set by GPU incumbents, and teased another part for 2028.
• Customer signal: Saudi AI firm Humain plans to deploy Qualcomm’s accelerators at scale, targeting 200 MW starting in 2026.
• Investor angle: A credible roadmap and anchor deployments can reposition Qualcomm beyond handsets—making it one of today’s biggest stock movers in semis.

HIVE Digital Technologies (NASDAQ: HIVE) +2% — Hashrate milestone underscores scaling push

• Capacity: HIVE surpassed 22 EH/s of global Bitcoin‑mining capacity, up 267% year to date.
• Economics: Current production is ~9.5 BTC/day with fleet efficiency near 17.8 J/TH and a 55% mining margin at a $47 hashprice.
• Outlook: Additional ASICs are slated to lift capacity to 25 EH/s by U.S. Thanksgiving, with a targeted 17.5 J/TH efficiency.
• Takeaway: In digital infrastructure, EH/s expansion and efficiency gains are key valuation levers, helping keep HIVE on the list of biggest stock movers.

Biggest stock movers: Top losers under pressure

Genenta Science (NASDAQ: GNTA) -43% — Dilution fears follow $15M capital raise

• Financing: The company entered a securities purchase agreement with institutional investors, selling ~4.29M ADSs at $3.50 each; no warrants attached.
• Use of proceeds: Working capital and general corporate purposes.
• Timing: Closing expected on or around Oct. 28, 2025.
• Lens: Small‑cap biotech financings often spark sharp reratings, placing GNTA among Monday’s biggest stock movers to the downside.

Organon (NYSE: OGN) -21% — CEO exits amid wholesaler sales probe; controls tightened

• Leadership: CEO Kevin Ali resigned following an audit committee investigation into improper sales practices tied to contraceptive Nexplanon.
• Findings: U.S. wholesalers were encouraged to buy excess inventory across multiple quarters from 2022 to 2025; the activity represented less than 1% of revenue but aided in meeting guidance.
• Governance moves: Joseph Morrissey (EVP, Manufacturing & Supply) named interim CEO; Chair Carrie Cox becomes executive chair; Robert Essner appointed lead independent director. The Head of U.S. Commercial & Government Affairs was terminated. The probe did not find CFO involvement.
• Focus: Strengthened financial controls and a search for a permanent CEO are underway, making OGN one of the day’s biggest stock movers in health care.

Gold Fields (NYSE: GFI) -8% — Miners retreat as supply fears cool on trade headlines

• Sector swing: U.S.‑listed miners fell after officials suggested China may delay export controls on critical minerals as part of a broader trade deal, easing earlier supply concerns.
• Peer moves: Critical Metals (CRML) -18%+, USA Rare Earth (USAR) -13%, MP Materials (MP) -9%, Trilogy Metals (TMQ) -18%, Energy Fuels (UUUU) -14%, NioCorp (NB) -16%.
• Read‑through: As supply‑risk premiums fade, investors rotate out of prior winners—landing miners among the biggest stock movers on the downside.

POET Technologies (NASDAQ: POET) -4% — Capital raise adds cash runway, trims shares

• Deal: Oversubscribed registered direct offering of ~20.69M common shares to raise roughly $150M in gross proceeds; closing expected on or about Oct. 28, 2025.
• Strategy: Funds targeted for corporate development, selective acquisitions, R&D scale‑up, light‑source business acceleration, operations expansion and working capital.
• Liquidity: Pro forma cash projected to exceed $300M post‑closing.
• Dynamic: Share issuances frequently weigh on near‑term price action, keeping POET among today’s biggest stock movers.

Context and background: Macro drivers behind the moves

The day’s risk tone reflects three tailwinds:

• Trade optimism: Hints of progress on a US‑China deal reduced some geopolitical overhang and helped cyclical pockets.
• Policy expectations: Markets have largely priced a Fed rate cut this week, supporting rate‑sensitive sectors and broad equity futures.
• Earnings season: With mega‑cap tech reporting, positioning and guidance will likely recalibrate leadership, potentially reshuffling the leaderboard of biggest stock movers throughout the week.

Sector‑specific trends also matter:

• Biotech: M&A remains a key catalyst amid looming patent cliffs for large pharma.
• AI hardware: New entrants and architectures are widening the addressable market for inference and training—opening wallet share battles beyond GPUs.
• Materials: Policy‑driven supply narratives can quickly reverse, as seen in miners’ pullback on export‑control headlines.

Reactions and updates: What pros are watching

• Deal spreads: Event‑driven desks will track Avidity’s price relative to the $72 takeout and any regulatory commentary from Novartis.
• AI deployments: Follow‑through orders, pilot wins and third‑party benchmarks will help validate Qualcomm’s accelerator roadmap.
• Crypto infra metrics: For HIVE, incremental EH/s, fleet efficiency and realized hashprice are the KPIs that drive revenue sensitivity.
• Governance and controls: Organon’s interim leadership steps and any restatements or guidance revisions will be closely watched.
• Miners’ beta: If trade headlines persist, gold and rare‑earth names may continue to see position trimming.
• Cash runway: POET’s deployment cadence and M&A prioritization could shape sentiment once the capital raise closes.

These moving parts could shuffle the list of biggest stock movers intraday as new filings, guidance and headlines hit the tape.

The bottom line

Firmer futures, policy optimism and a blockbuster earnings slate set an upbeat stage, while idiosyncratic catalysts turned select names into the biggest stock movers. Avidity’s premium buyout, Qualcomm’s aggressive AI push and sector cross‑currents in miners and health care define the day’s narrative. As results roll in and policy headlines evolve, expect leadership to rotate—and keep an eye on liquidity, guidance quality and execution to separate durable trends from one‑day pops.

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Article Source: Seeking Alpha
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